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London sarcoma service

Royal National Orthopaedic Hospital NHS Trust

University College London Hospitals NHS Foundation Trust

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our approach & expertise


research & clinical trials


recently closed trials

ALT-GIST: A randomized phase II trial of imatinib ALTernating with regorafenib compared to imatinib alone for first line treatment of advanced gastrointestinal stromal tumour (GIST)

ANNOUNCE I: A randomized, double-blind, placebo-controlled, phase 3 trial of olaratumab plus doxorubicin vs. placebo plus doxorubicin in patients with advanced or metastatic STS

CASPS: A Phase II Trial of Cediranib in the Treatment of Patients with Alveolar Soft Part Sarcoma (CASPS). This trial is testing a new drug cediranib that has already shown promising results in a small number of patients with alveolar soft part sarcoma. Cedirinib works by inhibiting growth of blood vessels in tumours.

CREATE: a cross-tumoral phase II trial exploring crizotinub (PF-02341066) in patients with advanced tumours induced by casual alterations of ALK and/or MET

Enliven: A Double-blind, Randomized, Placebo-controlled Phase 3 Study of Orally Administered PLX3397 in Subjects with Pigmented Villonodular Synovitis or Giant Cell Tumor of the Tendon Sheath

EQMR: Evaluating the feasibility of using whole body T1 mapping MRI in the assessment of differing tumour types and assessing response and changes in tumours to systemic oncological therapy.

EZH202: A phase II, multicentre study of the EZH202 Inhibitor Tazemetostat in adult subjects with INI1-Negative tumours or relapsed refractory Synovial and Epitheliod type

GeMCas: Molecular investigations into the genetic causes of multiple primary cancers: Pilot Phase

GOG-0277: A phase III randomised trial of gemcitabine plus docetaxel followed by doxorubicin versus observation for uterus-limited, high grade uterine leiomyosarcoma

MEMOS: A Mechanistic Study Of Mifamurtide (MTP-PE) In Patients With Metastatic And/Or Recurrent Osteosarcoma

Paragon: a phase II study of aromatase inhibitors in women with potentially hormone responsive recurrent/metastatic gynaecological neoplasms

RMS 2005: A protocol for non-metastatic rhabdomyosarcoma. This study is investigating the use of chemotherapy in the treatment of children and teenagers with rhabdomyosaroma that has not spread around the body.

STRASS: A phase III randomised trial of preoperative radiotherapy plus surgery versus surgery alone for patients with retroperitoneal sarcoma

VIT 0910: International randomized phase II trial of the combination of vincristine and ironotecan with or without temozolomide (VI or VIT) in children and adults with refractory or relapsed rhabdosarcoma.